Frequency of Recurrent IgA Nephropathy In Post Renal Transplant Patients In South Asian Population: A Single Center Study.

Abstract

Objective:   To determine the likelihood of recurrence of IgA Nephropathy in post-renal transplant patients with biopsy-confirmed IgA Nephropathy as the primary cause of renal failure.

Methods: This was a descriptive cross-sectional study that monitored the post-transplant progression of all renal transplant patients with biopsy-confirmed IgA nephropathy as the primary cause of end-stage renal disease. The cohort comprised 27 patients from a total of 960 diagnosed with biopsy-confirmed IgA Nephropathy as the etiology of renal failure. 

Results: In this study the mean age of the cases was 33.82 ± 10.84 years. There were 773 (80.5%) male and 187 (19.5%) females were enrolled. From total sample of 960 patients biopsy proven IgA neuropathy was observed in 27 (2.81%) patients. There were 21 (77.8%) male and 6 (22.2%) females were enrolled. All these patients 27 (100%) underwent kidney transplant. Recurrence was observed in 6 (22.2%) patients, 0 (0%) patients need dialysis after transplant, graft loss was observed in 0 (0%) patients. 

Conclusions: Outcomes of renal transplantation have significantly improved over time due to enhanced understanding of disease processes and immunology. Living-related kidney transplants in a resource-constrained environment have distinct limitations. The majority of patients arrive with advanced renal failure, and the fundamental etiology remains unidentified due to the absence of prompt tissue histology. Our study indicates that the recurrence rate of disease in IgA Nephropathy is 22%, aligning with global statistics. No discernible criteria can be established to forecast which patients would experience recurring disease, as the presentation is erratic.