Role of Statin and Frank Sign in Patients Experiencing PREACS Pain to Predict Major Adverse Cardiovascular Events

Abstract

Objective: to assess the role of statins and Frank's sign in predicting major adverse
cardiovascular events (MACE) among patients experiencing pre-acute coronary syndrome
(pre-ACS) pain.
Methodology: A cross sectional study was conducted at KRL Hospital from Oct 2021 to March
2022. One hundred and one patients of both genders, using statins for at least 1 year due to
Hypercholesterolemia, hospitalized for ACS, with or without ST-segment elevation, with an
onset of symptoms during the previous 24 hours were included in our study.
Data was analyzed using SPSS 26.0. Chi square test was applied to see the association
considering P values less than 0.05 as significant. Odds Ratio was calculated to see the risk of
disease
Results: Males were predominant with more than half of the study population. Frank sign was
observed in 56 patients out of which 29 patients (51.78%) developed Pre-ACS Pain having a p
value of 0.20. Patients with Frank sign have a 0.5 times risk of developing Pre-ACS pain. 48
(47.52%) patients reported no Frank sign out of which 38 (79.16%) were taking Atorvastatin &
10 (20.84%) are taking Rosuvastatin. Rosuvastatin.
Conclusion: Prescribing statins should be done on an individual basis based on expert clinical
opinion. Frank's sign has an extremely high correlation with pre-ACS pain. As a main preventive
measure, prescribe statins to reduce the risk of post-acute aches and pains.
Keywords: Frank sign, Pre-Acs pain, Acute Coronary syndrome, Primary Prevention.