Deciphering the Spectrum of Herpes Virus- An Overview

Abstract

Abstract

Infections caused by herpesviruses are severe particularly in immuno-susceptible individuals. Initial infection is followed by latency phase in ganglionic neurons. It is the period in which virus particles are not produced and no neuronal damage takes place. Once the virus is activated it results in viral replication which produces shingles in tissues that innervate neurons and causes consistent radicular pain called postherpatic neuralgia.  Other complications include cranial nerve palsies, stroke, meningitis, retinitis, ulcers and pancreatitis. Herpes viruses are abundantly associated with many other several pathological conditions associated with both humans and animals. Thus far, numerous approaches used to avert these infections have been ineffective because these viruses can circumvent different immune mechanisms. For this reason, better comprehension is needed to understand their complicated lifecycle. Currently, mass spectrometry has emerged as a crucial method that has permitted primitive findings in virology. In this review we discuss the prospective prosecution of high-through proteomic techniques to study proteomic streaming along with the post translational modifications that help in improving the molecular aspect of viral infection. It is hope in future that synergistic efforts will facilitate in the emergence of new procedure to fight against these viruses.

Keywords: herpesvirus, postherpatic neuralgia, latency, ganglionic neurons